IGSF11 antibody
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Name
IGSF11 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab04190
Tested Applications
ELISA, WB, IHC
Description
Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | immunoglobulin superfamily, member 11 (IGSF11) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 40-50kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q5DX21 |
| Gene ID | 152404 |
| Alias | CT119,VSIG3,BTIGSF,Igsf13,BT-IgSF,CXADRL1,V-set and immunoglobulin domain-containing protein ,Brain and testis-specific immunoglobulin superfamily protein |
| Background | Antibody anti-IGSF11 |
| Status | RUO |
| Note | Mol. Weight 40-50 kDa |
Background
IGSF11 is a transmembrane adhesion molecule primarily expressed in the brain, where it is localized at excitatory synapses. It contains Ig-like domains that mediate homophilic and heterophilic interactions with other synaptic proteins, influencing synaptic organization and plasticity. IGSF11 is essential for the stabilization of AMPA receptors, which are critical for synaptic transmission and long-term potentiation (LTP). Dysregulation of IGSF11 has been implicated in neurodevelopmental disorders such as autism spectrum disorders (ASD) and schizophrenia. It also plays a role in tumor biology, where it modulates cancer cell adhesion and migration in certain cancers.
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