Name: anti- IGF1R antibody
Brand: FineTest
SKU: FNab04170
Availability: OnlineOnly

Descripción

IGF1R, also named as CD221, is a receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). IGF1R binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity, the activated IGF1R is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cell. IGF1R is a heterotetrameric receptor, composed of two alpha subunits (130 kDa each) and two beta subunits (~98 kDa each) (PMID: 6279656). Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds.

Características del producto

clonality

polyclonal

reactivity

human,mouse,rat

immunogen target

insulin-like growth factor 1 receptor

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB, IHC, IF

observerd MW

70 kDa,90-100 kDa, 130 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

IGF1R

alias

Insulin-like growth factor 1 receptor,IGFR,CD221,IGFIR,JTK13,IGF-I receptor

uniprot id

https://www.uniprot.org/uniprotkb/P08069

gene id

https://www.ncbi.nlm.nih.gov/gene/3480

note

This product is for research use only.

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Human IGF1R(Insulin-like growth factor 1 receptor) ELISA Kit

proveedor

FineTest

reference

EH1371

reactivity

human

status

RUO

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