IDS antibody
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935106861
info@markelab.com
name
IDS antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04130
tested applications
ELISA, WB, IHC, IF
Description
Iduronate 2-sulfatase (IDS) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations causing IDS deficiency in humans result in the lysosomal storage of these glycosaminoglycans and Hunter syndrome, an X chromosome-linked disease. IDS is synthesized as two precursor forms of 76 and 90 kDa that are converted, through a 62 kDa intermediate, to 55 and 45 kDa mature polypeptides due to an internal proteolytic cleavage (PMID: 10838181).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | iduronate 2-sulfatase (IDS) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 2D2 |
| Observed MW | 76 kDa, 55 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P22304 |
| Gene ID | 3423 |
| Alias | Iduronate 2-sulfatase,Alpha-L-iduronate sulfate sulfatase (Idursulfase),Iduronate 2-sulfatase 42 kDa chain,Iduronate 2-sulfatase 14 kDa chain,IDS,SIDS |
| Background | Antibody anti-IDS |
| Status | RUO |
| Note | Mol. Weight 76 kDa, 55 kDa |
Descripción
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Iduronate 2-sulfatase (IDS) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations causing IDS deficiency in humans result in the lysosomal storage of these glycosaminoglycans and Hunter syndrome, an X chromosome-linked disease. IDS is synthesized as two precursor forms of 76 and 90 kDa that are converted, through a 62 kDa intermediate, to 55 and 45 kDa mature polypeptides due to an internal proteolytic cleavage (PMID: 10838181).
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