anti- Icam1 antibody
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935106861
info@markelab.com
name
anti- Icam1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04099
tested applications
ELISA, IHC, WB, FC
Description
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1(integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation(By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | intercellular adhesion molecule 1 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:1000-1:4000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 85-95 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB, FC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P13597 |
| Gene ID | 15894 |
| Alias | BB2,CD54,P3.58,ICAM-1 |
| Background | Antibody anti-ICAM1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Intercellular Adhesion Molecule 1 (ICAM-1) is a protein encoded by the ICAM1 gene in humans. It plays a crucial role in the immune response by aiding in the adhesion of leukocytes to the endothelial cells lining blood vessels. ICAM-1. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into respiratory epithelium. ICAM-1 is a transmembrane protein possessing an amino-terminus extracellular domain, a single transmembrane domain, and a carboxy-terminus cytoplasmic domain. The structure of ICAM-1 is characterized by heavy glycosylation, and the protein’s extracellular domain is composed of multiple loops created by disulfide bridges within the protein. ICAM-1 is important for the process of leukocyte extravasation, which is how white blood cells move from the bloodstream to infected or injured tissues. It helps leukocytes stick to endothelial cells, a crucial step in the inflammatory response. ICAM-1 can also trigger intracellular signaling events when it binds to its ligands, influencing cellular processes related to inflammation and immune responses.
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