HLTF antibody
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Description
Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters(By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair(PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | helicase-like transcription factor (HLTF) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 114 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q14527 |
| Gene ID | 6596 |
| Alias | Helicase-like transcription factor,DNA-binding protein/plasminogen activator inhibitor 1 regulator,HIP116,RING finger protein 80,RING-type E3 ubiquitin transferase HLTF,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3,Sucrose nonfermenting protein 2-like 3,HLTF,HIP116A,RNF80,SMARCA3,SNF2L3,ZBU1 |
| Background | Antibody anti-HLTF |
| Status | RUO |
| Note | Mol. Weight 114 kDa |
Descripción
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