HLA-G antibody
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Description
Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3). HLA-G is a non-classical MHC class I molecule with multiple immunoregulatory properties. HLA-G exhibits a restricted pattern of expression that includes placental extravillous trophoblasts at the maternal-fetal interface, where it abolishes maternal immune cell activity against fetus and establishes immune tolerance. Aberrant expression of HLA-G has been found in a variety of human neoplastic diseases. It plays an important role in the escape of tumor cells from immunosurveillance.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | MHC class I antigen G (HLA-G) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1:2000-1:10000; IHC: 1:50-1:200 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 3C12 |
| Observed MW | 38 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | protein A+G purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P17693 |
| Gene ID | 3135 |
| Alias | HLA class I histocompatibility antigen, alpha chain G,HLA G antigen,MHC class I antigen G,Soluble HLA class I histocompatibility antigen, alpha chain G (sHLA-G),HLA-G,HLA-6.0,HLAG |
| Background | Antibody anti-HLA-G |
| Status | RUO |
| Note | Mol. Weight 38 kDa |
Descripción
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Human sHLA-G (soluble HLA class I histocompatibility antigen, alpha chain G) ELISA Kit
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HLA-G antibody
Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3). HLA-G is a non-classical MHC class I molecule with multiple immunoregulatory properties. HLA-G exhibits a restricted pattern of expression that includes placental extravillous trophoblasts at the maternal-fetal interface, where it abolishes maternal immune cell activity against fetus and establishes immune tolerance. Aberrant expression of HLA-G has been found in a variety of human neoplastic diseases. It plays an important role in the escape of tumor cells from immunosurveillance.
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