HEY1 antibody
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Description
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'(PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3(PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal(PubMed:25985737).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | hairy/enhancer-of-split related with YRPW motif 1 (HEY1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 33 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9Y5J3 |
| Gene ID | 23462 |
| Alias | Hairy/enhancer-of-split related with YRPW motif protein 1,Cardiovascular helix-loop-helix factor 2 (CHF-2),Class B basic helix-loop-helix protein 31 (bHLHb31),HES-related repressor protein 1,Hairy and enhancer of split-related protein 1 (HESR-1),Hairy-related transcription factor 1 (HRT-1, hHRT1),HEY1,BHLHB31,CHF2,HERP2,HESR1,HRT1 |
| Background | Antibody anti-HEY1 |
| Status | RUO |
| Note | Mol. Weight 33 kDa |
Descripción
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