HCFC1 antibody
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Description
Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase(H3K4me) and Sin3 histone deacetylase(HDAC) complexes(involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus(HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | host cell factor C1(VP16-accessory protein) (HCFC1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 230 kDa, 300 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P51610 |
| Gene ID | 3054 |
| Alias | Host cell factor 1 (HCF, HCF-1),C1 factor,CFF,VCAF,VP16 accessory protein,HCF N-terminal chain 1,HCF N-terminal chain 2,HCF N-terminal chain 3,HCF N-terminal chain 4,HCF N-terminal chain 5,HCF N-terminal chain 6,HCF C-terminal chain 1,HCF C-terminal chain 2,HCF C-terminal chain 3,HCF C-terminal chain 4,HCF C-terminal chain 5,HCF C-terminal chain 6,HCFC1,HCF1,HFC1 |
| Background | Antibody anti-HCFC1 |
| Status | RUO |
| Note | Mol. Weight 230 kDa, 300 kDa |
Descripción
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HCFC1 antibody
Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase(H3K4me) and Sin3 histone deacetylase(HDAC) complexes(involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus(HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.
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Host Cell Factor 1 (HCFC1) Antibody
HCFC1 Antibody is a Rabbit Polyclonal antibody against HCFC1. This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
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