HACE1 antibody
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Description
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 (HACE1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 78 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8IYU2 |
| Gene ID | 57531 |
| Alias | E3 ubiquitin-protein ligase HACE1,HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1,HECT-type E3 ubiquitin transferase HACE1,HACE1,KIAA1320 |
| Background | Antibody anti-HACE1 |
| Status | RUO |
| Note | Mol. Weight 78 kDa |
Descripción
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