GRK6 antibody
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Description
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis(By similarity). Phosphorylates rhodopsin(RHO)(in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling(in vitro).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | G protein-coupled receptor kinase 6 (GRK6) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 66 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P43250 |
| Gene ID | 2870 |
| Alias | G protein-coupled receptor kinase 6,G protein-coupled receptor kinase GRK6,GRK6,GPRK6 |
| Background | Antibody anti-GRK6 |
| Status | RUO |
| Note | Mol. Weight 66 kDa |
Descripción
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