GRIA4 antibody
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Description
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | glutamate receptor, ionotrophic, AMPA 4 (GRIA4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 101 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P48058 |
| Gene ID | 2893 |
| Alias | Glutamate receptor 4 (GluR-4, GluR4),AMPA-selective glutamate receptor 4,GluR-D,Glutamate receptor ionotropic, AMPA 4 (GluA4),GRIA4,GLUR4 |
| Background | Antibody anti-GRIA4 |
| Status | RUO |
| Note | Mol. Weight 101 kDa |
Descripción
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