anti- GH2 antibody

Este producto es parte de GH2 - Growth hormone 2
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935106861
info@markelab.com
name
anti- GH2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab03448
tested applications
ELISA, WB, IHC

Description

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Documents del producto

Instrucciones
Descargar
Data sheet

Product specifications

Category
Primary Antibodies
Immunogen Target
growth hormone 2
Host
Rabbit
Reactivity
human,mouse,rat
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
23-25kd
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P01242
Gene ID
2689
Alias
GHL,GHV,GH-V,GHB2,hGH-V,Growth hormone variant,Placenta-specific growth hormone
Background
Antibody anti-GH2
Status
RUO
Note
This product is for research use only.

Descripción

Growth hormone 2 (GH2) is a member of the growth hormone gene family primarily expressed in the placenta, where it plays a critical role in regulating fetal growth and maternal metabolic adaptations during pregnancy GH2 is structurally similar to growth hormone 1 (GH1) but has distinct roles in enhancing placental development and nutrient transport to the fetus It stimulates insulin-like growth factor 1 (IGF-1) production and modulates maternal glucose and lipid metabolism to ensure fetal nutrient supply Dysregulation of GH2 expression has been associated with placental insufficiency, intrauterine growth restriction (IUGR), and gestational diabetes GH2 also influences immune responses during pregnancy, promoting tolerance to the fetus while maintaining maternal immunity Emerging studies suggest that alterations in GH2 expression may contribute to pregnancy complications and metabolic disorders, highlighting its importance in fetal development and maternal physiology

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