GABARAPL2 antibody

Product specifications

Primary Antibodies

GABA(A) receptor-associated protein-like 2 (GABARAPL2)

Rabbit

Human, Mouse, Rat

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:50

polyclonal

Unconjugated

IgG

14 kDa

≥95% as determined by SDS-PAGE

Immunogen affinity purified

100µg

liquid

ELISA, WB, IHC, IF

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

P60520

11345

ATG8,ATG8C,GATE-16,GATE16,GEF-2,GEF2

Antibody anti-GABARAPL2

RUO

Mol. Weight 14 kDa

GABARAPL2, another member of the GABARAP family, is essential for receptor trafficking, intracellular transport, and autophagy regulation. Like GABARAPL1, GABARAPL2 interacts with GABA-A receptors to facilitate their trafficking and proper membrane localization, maintaining synaptic inhibitory neurotransmission. It is also a core component of the autophagy machinery, functioning in autophagosome formation and lysosomal delivery of cargo proteins. GABARAPL2 interacts with autophagy-related proteins like LC3 and ATG8 to mediate selective autophagy processes, including the degradation of misfolded proteins and damaged organelles. Dysregulation of GABARAPL2 is associated with neurodegenerative disorders, such as Huntington’s and ALS, where defective autophagy contributes to protein aggregation and neuronal loss. In cancer, GABARAPL2 plays a dual role, promoting survival or apoptosis depending on cellular context, highlighting its involvement in tumor growth and chemoresistance. Its role in maintaining cellular homeostasis through autophagy and receptor regulation makes GABARAPL2 a promising therapeutic target for neurodegenerative diseases and cancer.

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