FSHR antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
FSHR antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab10096
Tested Applications
ELISA, IHC
Description
Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | follicle stimulating hormone receptor (FSHR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1:50 - 1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 71 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P23945 |
| Gene ID | 2492 |
| Alias | FSHR,Follitropin receptor,LGR1 ,FSH-R,FSHRO,ODG1 |
| Background | Antibody anti-FSHR |
| Status | RUO |
| Note | Mol. Weight 71 kDa |
Background
FSHR is a G protein-coupled receptor that binds follicle-stimulating hormone (FSH), a glycoprotein hormone essential for reproductive function. FSHR is primarily expressed in ovarian granulosa cells and testicular Sertoli cells, where it regulates gametogenesis, follicular development, and estrogen production. In females, FSHR activation stimulates granulosa cell proliferation, estradiol synthesis, and follicular maturation, critical for ovulation and fertility. In males, FSHR promotes Sertoli cell function and spermatogenesis. FSHR signaling occurs through Gs proteins, leading to activation of adenylyl cyclase, increased cAMP levels, and downstream activation of PKA and MAPK pathways. Mutations in FSHR can cause reproductive disorders such as ovarian dysgenesis, primary ovarian insufficiency, and male infertility. FSHR overexpression has been observed in ovarian cancer, where it may contribute to tumor growth. Therapeutically, FSH analogs are used in assisted reproduction technologies to stimulate ovarian function, while FSHR inhibitors are under investigation for treating hormone-driven cancers.
Productos relacionados
Follicle Stimulating Hormone Receptor (FSHR) Antibody
FSHR Antibody is a Rabbit Polyclonal antibody against FSHR. FSHR, also named as LGR1, belongs to the G-protein coupled r…
Ver producto
Follicle Stimulating Hormone Receptor (FSHR) Antibody
Rabbit polyclonal antibody against FSHR protein. Immunogen region is Internal.…
Ver producto
Follicle Stimulating Hormone Receptor (FSHR) Antibody
Rabbit polyclonal antibody against FSHR protein. Immunogen region is Internal.…
Ver producto