ABRAXAS1 antibody
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Description
Involved in DNA damage response and double-strand break(DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | family with sequence similarity 175, member A (ABRAXAS1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2400; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 46 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q6UWZ7 |
| Gene ID | 84142 |
| Alias | BRCA1-A complex subunit Abraxas 1,Coiled-coil domain-containing protein 98,Protein FAM175A,ABRAXAS1,ABRA1,CCDC98,FAM175A |
| Background | Antibody anti-ABRAXAS1 |
| Status | RUO |
| Note | Mol. Weight 46 kDa |
Descripción
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