anti- ESRRB antibody
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935106861
info@markelab.com
name
anti- ESRRB antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02871
tested applications
ELISA, WB, IP
Description
Nuclear receptor, may regulate ESR1 transcriptional activity. Induces the expression of PERM1 in the skeletal muscle.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | estrogen-related receptor beta |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 45-49 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O95718 |
| Gene ID | 2103 |
| Alias | ERR2,ERRb,ESRL2,NR3B2,DFNB35,ERRbeta2,ERR beta-2,Steroid hormone receptor ERR2,Estrogen receptor-like 2,Nuclear receptor subfamily 3 group B member 2 |
| Background | Antibody anti-ESRRB |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Estrogen related receptor beta (ESRRB) is another member of the estrogen-related receptor family, playing a key role in regulating embryonic development, stem cell maintenance, and metabolic homeostasis ESRRB, also known as ERRβ, is expressed in a variety of tissues, including the brain, lung, and reproductive organs, where it regulates the expression of genes involved in stem cell differentiation, energy metabolism, and cellular stress responses ESRRB is crucial for the development and function of the central nervous system, and it is involved in neurogenesis and synaptic plasticity Additionally, ESRRB plays a role in regulating lipid metabolism and insulin sensitivity, influencing energy homeostasis and fat storage in tissues like the liver and adipose tissue Dysregulation of ESRRB has been associated with diseases such as neurodegenerative disorders, obesity, and metabolic syndrome, where impaired energy regulation and mitochondrial dysfunction contribute to disease progression Its involvement in stem cell maintenance and tissue regeneration makes ESRRB a potential target for regenerative medicine and cancer therapies
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