ERI1 antibody
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Description
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs(siRNAs) in vitro, suggesting a possible role as regulator of RNA interference(RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | exoribonuclease 1 (ERI1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 46kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8IV48 |
| Gene ID | 90459 |
| Alias | 3'-5' exoribonuclease 1,3'-5' exonuclease ERI1,Eri-1 homolog,Histone mRNA 3'-end-specific exoribonuclease,Histone mRNA 3'-exonuclease 1,Protein 3'hExo (HEXO),ERI1,3'EXO,THEX1 |
| Background | Antibody anti-ERI1 |
| Status | RUO |
| Note | Mol. Weight 46 kDa |
Descripción
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