ENTPD1 antibody
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Name
ENTPD1 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab02781
Tested Applications
ELISA, WB, IF
Description
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:1000; IF: 1:20-1:200 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 2D3 |
| Observed MW | 58 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P49961 |
| Gene ID | 953 |
| Alias | CD39,SPG64,ATP-DPH,ATPDase,NTPDase-1,ATP diphosphohydrolase,Ecto-ATP diphosphohydrolase 1,Ecto-apyrase,Lymphoid cell activation antigen ,Nucleoside triphosphate diphosphohydrolase 1 |
| Background | Antibody anti-ENTPD1 |
| Status | RUO |
| Note | Mol. Weight 58 kDa |
Background
ENTPD1, also known as CD39, is a critical ectoenzyme involved in the regulation of extracellular nucleotide levels. It belongs to the family of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases) that hydrolyze extracellular nucleotides, such as ATP and ADP, into their respective monophosphate forms (AMP). This enzymatic activity is crucial for modulating purinergic signaling, which is involved in various physiological processes, including immune responses, thrombosis, vascular function, and tissue homeostasis. ENTPD1 is primarily expressed on immune cells like T regulatory cells (Tregs), dendritic cells, macrophages, and endothelial cells. Its ability to degrade ATP and ADP limits pro-inflammatory and pro-thrombotic signaling, promoting an anti-inflammatory and antithrombotic environment. This makes ENTPD1 a significant player in maintaining immune tolerance, regulating inflammation, and controlling thrombosis.
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