EDN1 antibody
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935106861
info@markelab.com
name
EDN1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02763
tested applications
ELISA, WB, IHC
Description
This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | endothelin 1 (EDN1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 24 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P05305 |
| Gene ID | 1906 |
| Alias | ARCND3,ET1, ET-1,HDLCQ7,QME,PPET1 |
| Background | Antibody anti-EDN1 |
| Status | RUO |
| Note | Mol. Weight 24 kDa |
Descripción
Endothelin-1 (EDN1) is a peptide hormone belonging to the endothelin family. It plays a crucial role in regulating blood vessel contraction and dilation, thereby influencing blood pressure and blood flow throughout the body. Endothelin-1 is primarily produced by endothelial cells, It is also produced by other cell types, including vascular smooth muscle cells, cardiomyocytes, and certain inflammatory cells.Endothelin-1 acts as a potent vasoconstrictor, meaning it causes blood vessels to narrow, leading to an increase in blood pressure. Dysregulation of endothelin-1 signaling is associated with several cardiovascular disorders, including hypertension, atherosclerosis, coronary artery disease, and pulmonary hypertension. Elevated levels of endothelin-1 have been observed in individuals with these conditions, contributing to their pathogenesis. Endothelin-1 is able to bind to specific receptors on target cells known as endothelin receptors. There are two main types of endothelin receptors: endothelin receptor type A (ETA) and endothelin receptor type B (ETB).
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EDN1 antibody
This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants.
Ver Producto