EEF1E1 antibody
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Name
EEF1E1 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab02649
Tested Applications
ELISA, IHC, WB
Description
Positive modulator of ATM response to DNA damage.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | eukaryotic translation elongation factor 1 epsilon 1 (EEF1E1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 20kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O43324 |
| Gene ID | 9521 |
| Alias | AIMP3, P18,EEF1E1 |
| Background | Antibody anti-EEF1E1 |
| Status | RUO |
| Note | Mol. Weight 20 kDa |
Background
EEF1E1 is a subunit of the eukaryotic elongation factor 1 (eEF1) complex, which plays a critical role in protein synthesis by facilitating the recruitment of aminoacyl-tRNA to the ribosome during elongation. EEF1E1 functions as a structural component, stabilizing the interaction between other subunits, such as EEF1A and EEF1B, within the eEF1 complex. It is also involved in regulating the exchange of GDP for GTP on EEF1A, a critical step in elongation cycle progression. EEF1E1 is expressed ubiquitously, reflecting its essential role in maintaining efficient protein translation in all cells. Dysregulation of EEF1E1 has been linked to cancer progression, where increased protein synthesis supports tumor growth and proliferation. It is also implicated in neurodegenerative diseases, where disruptions in protein homeostasis and elongation factor function are contributing factors. Further studies are needed to explore its broader roles in translational control and disease pathology.
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