DOK4 antibody
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Name
DOK4 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab02503
Tested Applications
ELISA, IHC
Description
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway(By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | docking protein 4 (DOK4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 37 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8TEW6 |
| Gene ID | 55715 |
| Alias | Downstream of tyrosine kinase 4,Insulin receptor substrate 5,IRS-5,IRS5 |
| Background | Antibody anti-DOK4 |
| Status | RUO |
| Note | Mol. Weight 37 kDa |
Background
DOK4 is an adaptor protein belonging to the DOK family, involved in signal transduction downstream of receptor tyrosine kinases, such as RET and insulin receptors. It modulates pathways like MAPK/ERK and PI3K/Akt, influencing cellular proliferation, survival, and differentiation. DOK4 is expressed in tissues like skeletal muscle, adipose tissue, and the nervous system, where it regulates metabolic signaling and cellular responses. It acts as a negative regulator of signaling by binding to SH2 domains and inhibiting downstream activation. Dysregulation of DOK4 is associated with metabolic disorders, insulin resistance, and certain cancers, where it influences cell adhesion and motility.
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