DOCK1-Specific antibody
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935106861
info@markelab.com
name
DOCK1-Specific antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02493
tested applications
ELISA, WB, IF
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | dedicator of cytokinesis 1 (DOCK1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2400; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 180kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q14185 |
| Alias | DOCK1, DOCK180, ced5, Dock180, dedicator of cytokinesis 1 |
| Background | Antibody anti-DOCK1 |
| Status | RUO |
| Note | Mol. Weight 180 kDa |
DOCK1, also known as DOCK180, is a GEF that activates Rac1 GTPase, regulating cytoskeleton rearrangement and cell migration. It forms a DOCK1–ELMO–Crk complex for Rac1 activation, driving lamellipodia formation and cell motility. DOCK1 is crucial for phagocytosis, cell polarity, neural crest migration, and cardiovascular development. Overexpression links to cancer metastasis by promoting tumor motility. It localizes to cytoplasm and membrane ruffles during migration and is regulated via phosphorylation and scaffold interactions. Knockout studies in mice reveal its role in embryonic viability, neuronal differentiation, and immune responses, highlighting its importance in cell adhesion and morphology.
