DNAJC10 antibody
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Description
Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation(ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DnaJ(Hsp40) homolog, subfamily C, member 10 (DNAJC10) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 75-80 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8IXB1 |
| Gene ID | 54431 |
| Alias | DnaJ homolog subfamily C member 10,Endoplasmic reticulum DNA J domain-containing protein 5 (ER-resident protein ERdj5, ERdj5),Macrothioredoxin (MTHr),DNAJC10,ERDJ5 |
| Background | Antibody anti-DNAJC10 |
| Status | RUO |
| Note | Mol. Weight 75-80 kDa |
Descripción
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