CYP11B2 antibody

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935106861
info@markelab.com
name
CYP11B2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02144
tested applications
ELISA, IHC, WB, IF

Description

Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
cytochrome P450, family 11, subfamily B, polypeptide 2 (CYP11B2)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
50 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, IHC, WB, IF
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P19099
Gene ID
1585
Alias
Cytochrome P450 11B2, mitochondrial,Aldosterone synthase (ALDOS),Aldosterone-synthesizing enzyme,CYPXIB2,Corticosterone 18-monooxygenase, CYP11B2,Cytochrome P-450Aldo,Cytochrome P-450C18,Steroid 11-beta-hydroxylase, CYP11B2,Steroid 18-hydroxylase,CYP11B2
Background
Antibody anti-CYP11B2
Status
RUO
Note
Mol. Weight 50 kDa

Descripción

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.

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