CXCR2 antibody

Este producto es parte de CXCR - C-X-C motif chemokine receptor
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935106861
info@markelab.com
name
CXCR2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02100
tested applications
ELISA, WB, IF, IP

Description

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
interleukin 8 receptor, beta (CXCR2)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000; IP:1:200-1:1000; IHC: 1:50-1:200; IF: 1:20-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
45-50 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IF, IP
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P25025
Gene ID
3579
Alias
CXCR2,C-X-C motif chemokine receptor 2,CD182,IL8R2,IL8RA,IL8RB,CMKAR2,WHIMS2,CDw128b,KC receptor,CXC-R2,high affinity interleukin-8 receptor B,CD128,Gpcr16
Background
Antibody anti-CXCR2
Status
RUO
Note
Mol. Weight 45-50 kDa

Descripción

CXCR2 is a G protein-coupled receptor that binds IL-8 and other CXC chemokines like Groα, Groβ, and NAP-2. It is mainly expressed on neutrophils, endothelial cells, and monocytes, mediating chemotaxis, neutrophil activation, and cytokine release during inflammation. CXCR2 signaling activates pathways such as PI3K, MAPK, and NF-κB, while its rapid desensitization and internalization regulate signal duration. CXCR2 is critical for immune surveillance and inflammation but also contributes to diseases like COPD, asthma, and rheumatoid arthritis due to excessive neutrophil infiltration. In cancer, CXCR2 promotes tumor progression, angiogenesis, and metastasis by recruiting myeloid-derived suppressor cells (MDSCs) and endothelial cells to the tumor microenvironment, enhancing immunosuppression and vascularization. CXCR2 inhibition reduces tumor growth and inflammation, highlighting its therapeutic potential. It also regulates leukocyte trafficking and tissue repair but contributes to pathologies like cystic fibrosis and inflammatory bowel disease (IBD) when dysregulated. Overall, CXCR2 is key for immune cell recruitment and inflammation, balancing host defense with disease progression.

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