CPT1C antibody
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Description
May play a role in lipid metabolic process.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | carnitine palmitoyltransferase 1C (CPT1C) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:1000; IHC: 1:20-1:200 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 4E4 |
| Observed MW | 82kD |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8TCG5 |
| Gene ID | 126129 |
| Alias | Palmitoyl thioesterase CPT1C,Carnitine O-palmitoyltransferase 1, brain isoform (CPTI-B),Carnitine palmitoyltransferase 1C,Carnitine palmitoyltransferase I (CPT I-C),CPT1C,CATL1 |
| Background | Antibody anti-CPT1C |
| Status | RUO |
| Note | Mol. Weight 82 kDa |
Descripción
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Carnitine O-Palmitoyltransferase 1, Brain Isoform (CPT1C) Antibody
The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine.
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