CPSF6 antibody

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935106861
info@markelab.com
name
CPSF6 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01940
tested applications
ELISA, WB, IHC, IP

Description

Component of the cleavage factor Im complex(CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
cleavage and polyadenylation specific factor 6, 68kDa (CPSF6)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
55-68 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC, IP
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q16630
Gene ID
11052
Alias
Cleavage and polyadenylation specificity factor subunit 6,Cleavage and polyadenylation specificity factor 68 kDa subunit (CPSF 68 kDa subunit),Cleavage factor Im complex 68 kDa subunit (CFIm68),Pre-mRNA cleavage factor Im 68 kDa subunit,Protein HPBRII-4/7,CPSF6,CFIM68
Background
Antibody anti-CPSF6
Status
RUO
Note
Mol. Weight 55-68 kDa

Descripción

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Component of the cleavage factor Im complex(CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.

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The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.

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