CNRIP1 antibody
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935106861
info@markelab.com
name
CNRIP1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01818
tested applications
ELISA, WB, IHC
Description
Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | cannabinoid receptor interacting protein 1 (CNRIP1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 13-25kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q96F85 |
| Gene ID | 25927 |
| Alias | CNRIP1,CRIP1,CRIP-1,C2orf32 |
| Background | Antibody anti-CNRIP1 |
| Status | RUO |
| Note | Mol. Weight 13-25 kDa |
Descripción
Cannabinoid receptor interacting protein 1 (CNRIP1) is an intracellular protein that interacts with cannabinoid receptors, specifically CB1 (cannabinoid receptor type 1), which is primarily found in the central nervous system and plays a pivotal role in modulating various physiological processes, including pain perception, appetite, and mood. CNRIP1 is thought to be involved in regulating the signaling pathways of CB1, modulating its activity, and potentially impacting receptor desensitization or internalization. Through its interaction with CB1, CNRIP1 indirectly participates in the endocannabinoid system, which maintains homeostasis in processes such as synaptic transmission, immune response, and neuroprotection. Beyond the nervous system, CNRIP1 may also influence metabolic and energy balance functions, as CB1 receptors are expressed in peripheral tissues like adipose tissue, liver, and skeletal muscle. Aberrant expression or function of CNRIP1 has been implicated in pathological conditions such as obesity, neurodegenerative disorders, and substance use disorders, highlighting its potential as a target for therapeutic interventions. CNRIP1 continues to be an area of active research, with a focus on elucidating its precise molecular mechanisms and broader implications in cannabinoid receptor-mediated pathways.
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