Name: anti- CLSPN antibody
Brand: FineTest
SKU: FNab01775
Availability: OnlineOnly

Descripción

Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex(pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.

Características del producto

clonality

polyclonal

reactivity

human

immunogen target

claspin homolog(Xenopus laevis)

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB, IF, IP

observerd MW

240 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:200-1:1000; IP: 1:500-1:2000; IF: 1:20-1:200

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

CLSPN

uniprot id

https://www.uniprot.org/uniprotkb/Q9HAW4

gene id

https://www.ncbi.nlm.nih.gov/gene/63967

note

This product is for research use only.

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