DDIT3 antibody

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935106861
info@markelab.com
name
DDIT3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01667
tested applications
ELISA, IHC, WB

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
DNA-damage-inducible transcript 3 (DDIT3)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
30 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, IHC, WB
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P35638
Gene ID
1649
Alias
DNA damage-inducible transcript 3 protein (DDIT-3),C/EBP zeta,C/EBP-homologous protein (CHOP),C/EBP-homologous protein 10 (CHOP-10),CCAAT/enhancer-binding protein homologous protein,Growth arrest and DNA damage-inducible protein GADD153,DDIT3,CHOP,CHOP10,GADD153
Background
Antibody anti-DDIT3
Status
RUO
Note
Mol. Weight 30 kDa

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CHOP, also known as GADD153 or DDIT3, is a highly conserved gene in both the structural and regulatory regions to hamster gene.Imposed by unfolded and malfolded proteins, CHOP is significantly induced by ER stress, deficiency of CHOP prevents cell from ER stress. CHOP is considered a proapoptotic marker of ER stress dependent cell death. CHOP acts as a dominant-negative inhibitor of the transcription factor C/EBP and LAP by forming a heterodimer. It may play an important role in the malignant transformation of nevus to melanoma.

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