anti- CHL1 antibody
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Description
Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane(By similarity).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | cell adhesion molecule with homology to L1CAM(close homolog of L1) |
| Host | Rabbit |
| Reactivity | human,mouse |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 135 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O00533 |
| Gene ID | 10752 |
| Alias | CAL, L1CAM2,Close homolog of L1,Neural cell adhesion molecule L1-like protein |
| Background | Antibody anti-CHL1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
CHL1, a member of the immunoglobulin superfamily, is closely related to L1CAM and plays a pivotal role in nervous system development and plasticity. CHL1 is expressed predominantly in the brain and spinal cord, where it mediates axon guidance, neuronal migration, and synapse formation by promoting cell-cell and cell-matrix adhesion. It contains extracellular immunoglobulin-like and fibronectin type III domains, facilitating its interactions with extracellular matrix proteins and other cell adhesion molecules. CHL1 is critical for axonal outgrowth, particularly in commissural axons, and contributes to neural circuit establishment during embryonic development. Mutations or altered expression of CHL1 have been linked to neurodevelopmental disorders, including schizophrenia and intellectual disability. CHL1 also interacts with intracellular signaling proteins, influencing cytoskeletal dynamics and neuronal polarity. Emerging evidence suggests that CHL1 may play a role in peripheral nervous system repair and regeneration following injury. Beyond the nervous system, CHL1 is implicated in cancer biology, where its dysregulation has been associated with tumor cell invasion and metastasis, particularly in glioblastoma. Its dual role in normal development and disease highlights CHL1 as a potential therapeutic target for both neurological and oncological conditions.
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