CEP290 antibody
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935106861
info@markelab.com
name
CEP290 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01602
tested applications
ELISA, WB, IP, IHC, IF
Description
Studies in the Chlamydomonas model system has shown that the ciliary protein CEP290 is a critical component of these Y-link junctions. Additionally, numerous studies have demonstrated that CEP290’s function is critical for IFT—in CEP290 knockdown experiments, many proteins that would normally localize to the cilium fail to do so, and cilium formation is disrupted or absent. Mutations in CEP290 are accountable for cases of nephronophthisis, Leber congenital amaurosis and Joubert syndrome. In IF analtsis of HeLa cells, the white arrows show centrosome and cilium staining.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | centrosomal protein 290kDa (CEP290) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:2000; IP: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 290 kDa, 150-180 kDa, 80 kDa, 60 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O15078 |
| Gene ID | 80184 |
| Alias | Centrosomal protein of 290 kDa (Cep290),Bardet-Biedl syndrome 14 protein,Cancer/testis antigen 87 (CT87),Nephrocystin-6,Tumor antigen se2-2,CEP290,BBS14,KIAA0373,NPHP6 |
| Background | Antibody anti-CEP290 |
| Status | RUO |
| Note | Mol. Weight 290 kDa, 150-180 kDa, 80 kDa, 60 kDa |
Descripción
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Studies in the Chlamydomonas model system has shown that the ciliary protein CEP290 is a critical component of these Y-link junctions. Additionally, numerous studies have demonstrated that CEP290’s function is critical for IFT—in CEP290 knockdown experiments, many proteins that would normally localize to the cilium fail to do so, and cilium formation is disrupted or absent. Mutations in CEP290 are accountable for cases of nephronophthisis, Leber congenital amaurosis and Joubert syndrome. In IF analtsis of HeLa cells, the white arrows show centrosome and cilium staining.
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