SLC3A2 antibody
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935106861
info@markelab.com
name
SLC3A2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01511
tested applications
ELISA, WB, IHC, IF, FC
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | solute carrier family 3(activators of dibasic and neutral amino acid transport), member 2 (SLC3A2) |
| Host | Rabbit |
| Reactivity | Human, rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 85 kDa, 120 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF, FC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P08195 |
| Alias | Amino acid transporter heavy chain SLC3A2,4F2 cell-surface antigen heavy chain (4F2hc),4F2 heavy chain antigen,Lymphocyte activation antigen 4F2 large subunit,Solute carrier family 3 member 2,SLC3A2,MDU1 |
| Background | Antibody anti-SLC3A2 |
| Status | RUO |
| Note | Mol. Weight 85 kDa, 120 kDa |
SLC7A5, also known as LAT1 (L-type amino acid transporter 1), is a transmembrane protein crucial for amino acid transport across the plasma membrane. It is part of the solute carrier family 7 (SLC7), specifically associated with the transport of large neutral amino acids (LNAAs) like leucine, isoleucine, valine, phenylalanine, and tryptophan, which are essential for various cellular functions. LAT1 is a high-affinity, sodium-independent transporter and functions as part of a heteromeric complex with SLC3A2 (4F2hc or CD98), which acts as a chaperone protein for the proper membrane localization and functionality of LAT1. SLC7A5 plays a significant role in cellular growth and proliferation, and it is highly expressed in rapidly dividing cells. It is abundant in tissues with high metabolic demands, such as the brain, placenta, and certain immune cells, as well as in many cancer cell types, where it facilitates the increased amino acid demand required for protein synthesis and tumor growth. LAT1 is also integral to the blood-brain barrier, as it enables the transport of essential amino acids into the brain, thereby impacting neurotransmitter synthesis.
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