CD86 antibody

Este producto es parte de CD86 molecule
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935106861
info@markelab.com
name
CD86 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01504
tested applications
ELISA, WB,IHC

Description

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

(Microbial infection) Acts as a receptor for adenovirus subgroup B.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
CD86 molecule (CD86)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:200-1:2000; IHC: 1:50-1:500; IF: 1:20-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
75 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB,IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P42081
Gene ID
942
Alias
B70,B7-2,B7.2,LAB72,CD28LG2,Activation B7-2 antigen,BU63,CTLA-4 counter-receptor B7.2,FUN-1,T-lymphocyte activation antigen CD86
Background
Antibody anti-CD86
Status
RUO
Note
Mol. Weight 75 kDa

Descripción

CD86, also known as B7-2, is a transmembrane glycoprotein that plays a crucial role in the costimulatory signaling necessary for T-cell activation and immune response. It is a member of the immunoglobulin (Ig) superfamily and is encoded by the CD86 gene located on chromosome 3q21. CD86 is primarily expressed on antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. The interaction of CD86 with its receptors, CD28 and CTLA-4 (CD152), on T cells is vital for regulating immune responses, influencing both the activation and inhibition of T cells.

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