anti- CD86 antibody

Name: anti- CD86 antibody
Brand: FineTest
SKU: FNab01504
Availability: OnlineOnly

Este producto es parte de CD86 molecule

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935106861

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Precio

Precio a consultar

Antibody anti-CD86

proveedor

FineTest

reference

FNab01504

Tested Applications

ELISA, WB,IHC

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Descripción

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B.

Background

CD86, also known as B7-2, is a transmembrane glycoprotein that plays a crucial role in the costimulatory signaling necessary for T-cell activation and immune response. It is a member of the immunoglobulin (Ig) superfamily and is encoded by the CD86 gene located on chromosome 3q21. CD86 is primarily expressed on antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. The interaction of CD86 with its receptors, CD28 and CTLA-4 (CD152), on T cells is vital for regulating immune responses, influencing both the activation and inhibition of T cells.

Características del producto

clonality

polyclonal

reactivity

human,mouse,rat

immunogen target

CD86 molecule

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB,IHC

observerd MW

75 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:200-1:2000; IHC: 1:50-1:500

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

CD86

alias

B70,B7-2,B7.2,LAB72,CD28LG2,Activation B7-2 antigen,BU63,CTLA-4 counter-receptor B7.2,FUN-1,T-lymphocyte activation antigen CD86

uniprot id

https://www.uniprot.org/uniprotkb/P42081

gene id

https://www.ncbi.nlm.nih.gov/gene/942

note

This product is for research use only.

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