anti- CD79A antibody

Name: anti- CD79A antibody
Brand: FineTest
SKU: FNab01499
Availability: OnlineOnly

Este producto es parte de CD79A molecule

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-CD79A

proveedor

FineTest

reference

FNab01499

Tested Applications

ELISA, WB, IHC

reactivity

human

status

RUO

clonality

polyclonal

Descripción

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex(BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro-and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Background

CD79A, also known as Ig-alpha, is a protein encoded by the CD79A gene in humans. It is a crucial component of the B cell receptor (BCR) complex, playing a significant role in B cell development, activation, and signaling. The BCR complex is essential for the adaptive immune response, allowing B cells to recognize and respond to specific antigens. CD79A, along with CD79B (Ig-beta), forms the signaling component of the BCR, transmitting signals from the antigen-bound surface immunoglobulin (Ig) to the cell's interior, initiating a cascade of intracellular events leading to B cell activation, proliferation, and differentiation.

Características del producto

clonality

polyclonal

reactivity

human

immunogen target

CD79a molecule, immunoglobulin-associated alpha

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB, IHC

observerd MW

40 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

CD79A

alias

IGA,MB1,MB-1,IGAlpha,Ig-alpha,MB-1 membrane glycoprotein,Membrane-bound immunoglobulin-associated protein,Surface IgM-associated protein,B-cell antigen receptor complex-associated protein alpha chain

uniprot id

https://www.uniprot.org/uniprotkb/P11912

gene id

https://www.ncbi.nlm.nih.gov/gene/973

note

This product is for research use only.

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