anti- CD45 antibody
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Precio
Precio a consultar
Antibody anti-PTPRC
proveedor
FineTestreference
FNab09780Tested Applications
ELISA, WB, IHC, FCreactivity
human,pigstatus
RUOclonality
monoclonalDescripción
CD45, also known as leukocyte common antigen(LCA), B220, and T200, is a 180-240 kD single chain type I membrane glycoprotein. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation.
Background
PTPRC, also known as CD45, is a receptor-type tyrosine phosphatase primarily expressed in hematopoietic cells. It regulates antigen receptor signaling in lymphocytes by dephosphorylating inhibitory residues on Src family kinases such as Lck and Fyn. Structurally, PTPRC has an extracellular domain, a single transmembrane region, and two cytoplasmic phosphatase domains, with the first being catalytically active. It is critical for T-cell and B-cell activation, development, and immune response regulation. Mutations in PTPRC are linked to severe immunodeficiency disorders, including SCID, and its overexpression is associated with autoimmune diseases and leukemia.
Características del producto
category
Primary Antibodies
clonality
monoclonal
reactivity
human,pig
immunogen target
protein tyrosine phosphatase, receptor type, C
host
Mouse
isotype
IgG2a
conjugation
Unconjugated
form
liquid
tested applications
ELISA, WB, IHC, FC
observerd MW
180-220 kDa
purity
≥95% as determined by SDS-PAGE
purification
Protein A+G purification
recommended dilution
WB: 1:1000-1:10000; IHC: 1:20-1:200
size 1
100µg
storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
or code
PTPRC
alias
LCA,LY5,B220,CD45,L-CA,T200,CD45R,GP180,IMD105,CD45,Leukocyte common antigen,Receptor-type tyrosine-protein phosphatase C
uniprot id
note
This product is for research use only.
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