CD38 antibody

Este producto es parte de CD38 - CD38 molecule
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935106861
info@markelab.com
name
CD38 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01472
tested applications
ELISA, WB, IHC

Description

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
CD38 molecule (CD38)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
42 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P28907
Gene ID
952
Alias
ADPRC1,Cadpr1,ADPRC 1,ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1,2'-phospho-ADP-ribosyl cyclase,2'-phospho-cyclic-ADP-ribose transferase,ADP-ribosyl cyclase 1,Cyclic ADP-ribose hydrolase 1
Background
Antibody anti-CD38
Status
RUO
Note
Mol. Weight 42 kDa

Descripción

CD38 is a multifunctional membrane glycoprotein expressed on a variety of cells, including immune cells (B cells, T cells, monocytes, and natural killer cells), as well as non-hematopoietic cells like those in the pancreas, brain, and muscle. Initially identified as a cell-surface receptor on lymphocytes, CD38 has since been recognized for its roles in enzyme-mediated metabolism, cell adhesion, and signal transduction. This protein is particularly well-known for its enzymatic activity in catalyzing the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+, which serves as an important second messenger in calcium signaling pathways. CD38 plays crucial roles in the regulation of intracellular calcium levels, influencing processes such as cell activation, proliferation, and differentiation.

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