MCAM antibody

Este producto es parte de MCAM - melanoma cell adhesion molecule
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935106861
info@markelab.com
name
MCAM antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01429
tested applications
ELISA, WB, IHC, FC

Description

CD146, also known as melanoma cell adhesion molecule(MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein belonging to the immunoglobulin(Ig) superfamily(PMID: 8378324). Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells(CECs)(PMID: 19356677).

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
melanoma cell adhesion molecule (MCAM)
Host
Mouse
Reactivity
Human
Recommended Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200
Clonality
monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Clone ID
0E4
Observed MW
113-120 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Protein A+G purification
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC, FC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P43121
Alias
Cell surface glycoprotein MUC18,CD146,MUC18,HEMCAM,METCAM,MelCAM,Cell surface glycoprotein P1H12,Melanoma-associated antigen A32,S-endo 1 endothelial-associated antigen
Background
Antibody anti-MCAM
Status
RUO
Note
Mol. Weight 113-120 kDa

Descripción

The melanoma cell adhesion molecule (MCAM), also known as CD146 or MUC18, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily (IgSF). MCAM was initially identified as an adhesion molecule highly expressed in melanoma cells, and since then, it has been shown to play a role in various cellular processes beyond melanoma, including angiogenesis, inflammation, and immune cell trafficking. MCAM is expressed in a variety of cell types, such as endothelial cells, smooth muscle cells, and immune cells, contributing to its diverse biological functions. Its key role in cellular adhesion makes it critical in both normal physiological processes like vascular integrity and in pathological conditions such as cancer metastasis, cardiovascular disease, and inflammation.

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