SDC1 antibody
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935106861
info@markelab.com
name
SDC1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01423
tested applications
ELISA, WB, IHC
Description
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | syndecan 1 (SDC1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 32 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P18827 |
| Gene ID | 6382 |
| Alias | SDC,CD138,SYND1 |
| Background | Antibody anti-SDC1 |
| Status | RUO |
| Note | Mol. Weight 32 kDa, 85-120 kDa |
Descripción
Syndecan-1 (SDC1), a cell surface heparan sulfate proteoglycan, is encoded by the SDC1 gene and is part of the syndecan family, which includes four distinct proteoglycans (syndecans 1-4). These proteoglycans are integral to cell surface structure, functioning in cellular communication, adhesion, migration, and the regulation of growth factors. Syndecan-1 is expressed on various cell types, including epithelial cells, B cells, and plasma cells, where it plays crucial roles in cell-matrix interactions and intracellular signaling. Additionally, SDC1 is dynamically regulated in response to tissue injury and inflammation, underscoring its significance in wound healing, inflammation, and cancer progression.
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