CASP10 antibody
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Description
This gene encodes a protein which is a member of the cysteine-aspartic acid protease(caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | caspase 10, apoptosis-related cysteine peptidase (CASP10) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 59kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q92851 |
| Gene ID | 843 |
| Alias | Caspase-10 (CASP-10),Apoptotic protease Mch-4,FAS-associated death domain protein interleukin-1B-converting enzyme 2 (FLICE2),ICE-like apoptotic protease 4,Caspase-10 subunit p23/17,Caspase-10 subunit p12,CASP10,MCH4 |
| Background | Antibody anti-CASP10 |
| Status | RUO |
| Note | Mol. Weight 59 kDa |
Descripción
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CASP10 antibody
This gene encodes a protein which is a member of the cysteine-aspartic acid protease(caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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