BTN3A1 antibody
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Name
BTN3A1 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab00983
Tested Applications
ELISA, WB
Description
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | butyrophilin, subfamily 3, member A1 (BTN3A1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 48 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O00481 |
| Gene ID | 11119 |
| Alias | BTF5,BT3.1,CD277,BTN3.1 |
| Background | Antibody anti-BTN3A1 |
| Status | RUO |
| Note | Mol. Weight 48 kDa |
Background
BTN3A, a member of the butyrophilin (BTN) family, is a type I transmembrane protein primarily involved in the modulation of immune responses. BTN3A is encoded by the BTN3A1, BTN3A2, and BTN3A3 genes, which are part of the larger BTN gene family located on chromosome 6 in humans. The BTN family is a subset of the immunoglobulin (Ig) superfamily and shares structural similarities with the B7 family of co-stimulatory molecules. BTN3A proteins are expressed in a variety of tissues, including immune cells like T cells and dendritic cells, indicating their significant role in immune system regulation. BTN3A1 isoform is the most extensively studied and is known for its role in the activation of γδ T cells. BTN3A1 interacts with phosphoantigens and facilitates their recognition by γδ T cells, leading to immune activation.
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