ATG4C antibody
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Description
Cysteine protease required for the cytoplasm to vacuole transport(Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation(By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine(PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATG4 autophagy related 4 homolog C (ATG4C) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 52-55 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q96DT6 |
| Gene ID | 84938 |
| Alias | Cysteine protease ATG4C,AUT-like 3 cysteine endopeptidase,Autophagy-related cysteine endopeptidase 3 (Autophagin-3),Autophagy-related protein 4 homolog C (HsAPG4C),ATG4C,APG4C,AUTL1,AUTL3 |
| Background | Antibody anti-ATG4C |
| Status | RUO |
| Note | Mol. Weight 52-55 kDa |
Descripción
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