ASZ1 antibody
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Description
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation(By similarity).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ankyrin repeat, SAM and basic leucine zipper domain containing 1 (ASZ1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 48-50kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8WWH4 |
| Gene ID | 136991 |
| Alias | Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1,Ankyrin-like protein 1,Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein,ASZ1,ALP1,ANKL1,C7orf7,GASZ |
| Background | Antibody anti-ASZ1 |
| Status | RUO |
| Note | Mol. Weight 48-50 kDa |
Descripción
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