ARHGEF5 antibody
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Description
Guanine nucleotide exchange factor which activates Rho GTPases(PubMed:15601624). Strongly activates RHOA(PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1(By similarity). Involved in regulation of cell shape and actin cytoskeletal organization(PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia(PubMed:14662653). Required for SRC-induced podosome formation(By similarity). Involved in positive regulation of immature dendritic cell migration(By similarity).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Rho guanine nucleotide exchange factor(GEF) 5 (ARHGEF5) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 60 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q12774 |
| Gene ID | 7984 |
| Alias | Rho guanine nucleotide exchange factor 5,Ephexin-3,Guanine nucleotide regulatory protein TIM,Oncogene TIM,Transforming immortalized mammary oncogene,p60 TIM,ARHGEF5,TIM |
| Background | Antibody anti-ARHGEF5 |
| Status | RUO |
| Note | Mol. Weight 60 kDa |
Descripción
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