ARHGEF4 antibody
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935106861
info@markelab.com
name
ARHGEF4 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00562
tested applications
ELISA, IHC, WB
Description
Acts as guanine nucleotide exchange factor(GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Rho guanine nucleotide exchange factor(GEF) 4 (ARHGEF4) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 72 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NR80 |
| Gene ID | 50649 |
| Alias | Rho guanine nucleotide exchange factor 4,APC-stimulated guanine nucleotide exchange factor 1 (Asef, Asef1),ARHGEF4,KIAA1112 |
| Background | Antibody anti-ARHGEF4 |
| Status | RUO |
| Note | Mol. Weight 72 kDa |
Descripción
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