APPL2 antibody
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935106861
info@markelab.com
name
APPL2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00517
tested applications
ELISA, WB
Description
Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (APPL2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 74 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8NEU8 |
| Gene ID | 55198 |
| Alias | DIP13B,Dip13-beta,Adapter protein containing PH domain, PTB domain and leucine zipper motif 2 |
| Background | Antibody anti-APPL2 |
| Status | RUO |
| Note | Mol. Weight 74 kDa |
Descripción
APPL2 (Phosphotyrosine Interacting with PH Domain and Leucine Zipper 2) is another member of the APPL protein family, similar to APPL1. Like APPL1, APPL2 also contains a pleckstrin homology (PH) domain and a leucine zipper, enabling it to interact with phosphotyrosine-containing proteins. APPL2 is involved in a wide range of cellular processes including endocytosis, signal transduction, and the regulation of vesicular trafficking. It is particularly important in regulating the function of the insulin receptor and in modulating signaling pathways that control cell growth, survival, and metabolism. APPL2 is known to affect cellular responses to growth factors and contributes to the regulation of neuronal function and plasticity. Its role in intracellular signaling makes it a relevant protein in understanding diseases like diabetes and neurodegenerative conditions.
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