APOBEC3G antibody
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Description
DNA deaminase(cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and-independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses(SIVs), hepatitis B virus(HBV), equine infectious anemia virus(EIAV), xenotropic MuLV-related virus(XMRV) and simian foamy virus(SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G (APOBEC3G) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 46 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9HC16 |
| Gene ID | 60489 |
| Alias | DNA dC->dU-editing enzyme APOBEC-3G,APOBEC-related cytidine deaminase (APOBEC-related protein, ARCD),APOBEC-related protein 9 (ARP-9),CEM-15 (CEM15),Deoxycytidine deaminase (A3G),APOBEC3G |
| Background | Antibody anti-APOBEC3G |
| Status | RUO |
| Note | Mol. Weight 46 kDa |
Descripción
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APOBEC3G antibody
DNA deaminase(cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and-independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses(SIVs), hepatitis B virus(HBV), equine infectious anemia virus(EIAV), xenotropic MuLV-related virus(XMRV) and simian foamy virus(SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
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This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified.
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