APLNR antibody
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935106861
info@markelab.com
name
APLNR antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00485
tested applications
ELISA, WB, IHC
Description
Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | apelin receptor (APLNR) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 43 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P35414 |
| Gene ID | 187 |
| Alias | APLNR,angiotensin receptor-like 1,AGTRL1 ,APJ,APJR,angiotensin II receptor-like 1 ,B78,GPCR34 , G-protein coupled receptor APJ,APJR, HG11 |
| Background | Antibody anti-APLNR |
| Status | RUO |
| Note | Mol. Weight 43 kDa |
Descripción
The Apelin receptor (APLNR), also known as angiotensin receptor-like 1 (APJ), is a G-protein-coupled receptor (GPCR) that binds the apelin peptide ligand. APLNR is involved in numerous physiological processes, particularly in the cardiovascular system, where it regulates heart development, blood pressure, and vascular tone. Apelin signaling via APLNR enhances cardiac contractility and contributes to angiogenesis, promoting the formation of new blood vessels during tissue growth or injury. It plays a protective role in heart failure by reducing cardiac hypertrophy and improving ejection fraction. Additionally, the apelin/APLNR pathway is critical for fluid homeostasis and water balance, as it regulates vasopressin release in the hypothalamus. In the central nervous system, APLNR influences neuroprotection and neurodevelopment, modulating processes like neuronal survival and axon growth. The receptor is also significant in metabolic regulation, as it improves insulin sensitivity and glucose uptake, highlighting its relevance to obesity and type 2 diabetes. Dysregulation of APLNR signaling is associated with hypertension, pulmonary arterial hypertension, and pre-eclampsia, conditions related to abnormal vascular function. Furthermore, it has been implicated in cancer progression, where it enhances tumor angiogenesis and promotes tumor cell migration. APLNR's diverse roles in cardiovascular health, neurobiology, and metabolism make it a promising therapeutic target for cardiovascular disease, diabetes, and cancer.
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Mouse Aplnr (Apelin receptor) ELISA Kit
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Apelin Receptor (APLNR) Antibody
APLNR Antibody is a Rabbit Polyclonal antibody against APLNR. This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.
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