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anti- APLNR antibody
proveedor
FineTestreference
FNab00485Tested Applications
ELISA, WB, IHCreactivity
human,mouse,ratstatus
RUOclonality
polyclonalDescripción
Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
Background
The Apelin Receptor (APLNR), also known as APJ, is a G protein-coupled receptor. APLNR serves as the receptor for two endogenous ligands: APELIN and ELABELA. It plays a crucial role in early development processes such as gastrulation, the formation of blood vessels, and the morphogenesis of the heart, primarily by acting as a receptor for the APELA hormone. Additionally, APLNR may facilitate the migration of angioblasts toward the embryonic midline, which is the future site of vessel formation, during the process of vasculogenesis. This receptor-ligand interaction is essential for orchestrating these critical developmental events
Background
El receptor de Apelina (APLNR), también conocido como APJ, es un receptor acoplado a proteína G. APLNR sirve como receptor de dos ligandos endógenos: APELIN y ELABELA. Desempeña un papel crucial en los procesos tempranos del desarrollo como la gastrulación, la formación de vasos sanguíneos y la morfogénesis del corazón, principalmente actuando como receptor de la hormona APELA. Además, APLNR puede facilitar la migración de angioblastos hacia la línea media embrionaria, que es el futuro sitio de formación de vasos, durante el proceso de vasculogénesis. Esta interacción receptor-ligando es esencial para orquestar estos eventos críticos del desarrollo.
Características del producto
category
Primary Antibodies
clonality
polyclonal
reactivity
human,mouse,rat
immunogen target
apelin receptor
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
liquid
tested applications
ELISA, WB, IHC
observerd MW
43 kDa
purity
≥95% as determined by SDS-PAGE
purification
Immunogen affinity purified
recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
size 1
100µg
storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
or code
APLNR
alias
APLNR,angiotensin receptor-like 1,AGTRL1 ,APJ,APJR,angiotensin II receptor-like 1 ,B78,GPCR34 | G-protein coupled receptor APJ,APJR, HG11
uniprot id
note
This product is for research use only.
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