APLF antibody
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Description
Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic(AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | aprataxin and PNKP like factor (APLF) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500 - 1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 60 kD |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8IW19 |
| Gene ID | 200558 |
| Alias | Aprataxin and PNK-like factor,Apurinic-apyrimidinic endonuclease APLF,PNK and APTX-like FHA domain-containing protein,XRCC1-interacting protein 1,APLF,C2orf13,PALF,XIP1 |
| Background | Antibody anti-APLF |
| Status | RUO |
| Note | Mol. Weight 60 kDa |
Descripción
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