anti- ANP32B antibody

Name: anti- ANP32B antibody
Brand: FineTest
SKU: FNab00447
Availability: OnlineOnly

Este producto es parte de ANP32 - Acidic leucine-rich nuclear phosphoprotein 32 family

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-ANP32B

proveedor

FineTest

reference

FNab00447

Tested Applications

ELISA, WB

reactivity

human

status

RUO

clonality

monoclonal

Descripción

Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A(PP2A) inhibitor activity(By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.

Background

ANP32B is a nuclear phosphoprotein that shares structural and functional similarities with ANP32A, particularly in chromatin regulation and RNA processing. ANP32B functions as a regulator of apoptosis, cell proliferation, and gene transcription, making it critical for cellular homeostasis and growth control. It is essential for embryonic development, with knockout studies indicating its requirement for cell survival and proper organogenesis. ANP32B also modulates the activity of HDAC complexes, contributing to histone deacetylation and transcriptional repression. Dysregulation of ANP32B has been linked to cancer progression and metastasis, where it promotes cell proliferation and resistance to apoptosis. Its involvement in multiple pathways underscores its importance as a potential therapeutic target in oncology.

Características del producto

clonality

monoclonal

reactivity

human

immunogen target

acidic(leucine-rich) nuclear phosphoprotein 32 family, member B

host

Mouse

isotype

IgG2b

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB

observerd MW

29 kDa

purity

≥95% as determined by SDS-PAGE

purification

Protein A+G purification

recommended dilution

WB: 1:500-1:2000; IF: 1:50-1:500

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

ANP32B

alias

ANP32B,APRIL,PHAPI2

uniprot id

https://www.uniprot.org/uniprotkb/Q92688

gene id

https://www.ncbi.nlm.nih.gov/gene/10541

note

This product is for research use only.

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